Welcome to the official web site for the International Workhops on Waldenstrom's Macroglobulinemia

The Third International Workshop on Waldenstrom's Macroglobulinemia, Paris 2004

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Conference Abstracts

Select from the list below to view the abstracts from the 2004 workshop in Paris. The abstracts are in PDF format and are organized by topic. Corresponding papers from this conference are scheduled to be published in the April 2005 edition of Clinical Lymphoma. These abstracts can also be accessed by following the links in the Paris program of events section.

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Genetic Basis and Pathogenesis

Origin of the Malignant Clone in WM. Linda M. Pilarski, Jitra Kriangkum, Tony Reiman, Michael J. Mant, Andrew R. Belch.

Evaluating Clonal Origins in Waldenstrom's Macroglobulinemia. S.S. Sahota.

FISH Analysis in Waldenstrom's Macroglobulinemia. Ocio EM, Hern�ndez JM, Gonz�lez B, Guti�rrez NC, D�ez-Campelo M, Castilla C, Ortega F, Aguilera C, Portero JA, B�rez A, Mart�n G, San Miguel JF.

DNA Cell Content Analysis and Cell Cycle Distribution in Patients with IgM Monoclonal Gammopathies. Mateo G, Ocio EM, Vidriales B, L�pez-Berges C, Hern�ndez JM, S�nchez ML, Orfao A, San Miguel JF

Gene Expression Profiling of WM - Biologic and Theraputic Implications. Fenghuang Zhan, Madhav Dhodapkar, Athanasios Fassas, Bart Barlogie, and John Shaughnessy, Jr.

Genomic Abnormalities in WM. R. Fonseca.

Constitutive Expression of CD40L on Bone Marrow Mast Cells Supports the Growth of Lymphoplasmacytic Cells in Patients with Waldenstrom's Macroglobulinemia. Olivier Tournilhac, Daniel Ditzel Santos, Lian Xu, Jeffery Kutok, Yu Tsu Tai, Steven Le Gouill, Evdoxia Hatjiharissi, Laurie Catley, Zachary Hunter, Andrew Branagan, Kenneth C Anderson and Steven P Treon

B-Lymphocyte Stimulator Protein (Blys) Is Expressed By Bone Marrow Mast And Lymphoplasmacytic Cells In Waldenstrom�s Macroglobulinemia, And Provides Signaling For Growth, Survival And Igm Secretion. Ditzel Santos D, Tournilhac O, Xu Lian, Hatjiharrisi E, Hunter Z, Branagan AR, Manning R, Anderson KC, Grewal I, Treon SP.

Predisposition to WM

Hepatitis C Virus Infection, Igm Monoclonal Gammopathy and WM. Franco Dammacco, Domenico Sansonno.

Single Nucleotide Polymorphism of the Hyaluronan Synthase 1 Gene-A Potential Predisposing Factor for WM. Sophia Adamia, Tony Reiman, Steven P. Treon, Michael J. Mant, Andrew R. Belch and Linda M. Pilarski.

Genetic Predisposition in WM. Robert Manning, Zachary Hunter, Suzanne Massota, Elizabeth Braverman, Abha Aggarwal, Charles Lee, Daniel Ditzel Santos, Evdoxia Hatjiharissi, Lian Xu, Olivier Tournilhac, Andrew R. Branagan, Cynthia Morton, and Steven P. Treon.

Long Term Follow-up of Familial Waldenstrom's Macroglobulinemia Kindreds. Mary L. McMaster, Theresa Giambaressi, Stephanie Saddlemire, Gyorgy Csako.

Marginal Zone Lymphoma and WM - Distinct or Same?

Clinicopathological Features Of Waldenstr�m�s Macroglobulinemia And Marginal Zone Lymphomas : Are They Distinct Or A Single Entity? F Berger, A Traverse-Glehen, P Felman, E Callet-Bauchu, C Thieblemont, M Ffrench, JP Magaud, G Salles, B Coiffier.

Differential Diagnosis of Waldenstrom's Macroglobulinemia(WM) and Other B-Cell Disorders (BCDs). Gerassimos A. Pangalis, Maria-Christina Kyrtsonis, Flora N. Kontopidou, Theodoros P. Vassilakopoulos, Marina P. Siakantaris, Maria N. Dimopoulou, Tatiana Tzenou, Styliani Kokoris, Evangelia Dimitriadou, Christina Kalpadaki, Caliroe Tsalimalma, Panagiotis Tsaftaridis, Panagiotis Panagiotidis, Maria K. Angelopoulou.

Correlation Between Size Of Igm M-Spike And Diagnosis In Chronic Lymphoproliferative Disorders. ED Remstein, WR Macon, RA Kyle, JM Hodnefield, PJ Kurtin.

Immunophenotypic And Cytogenetic Comparison Of Waldenstr�m�S Macroglobulinemia And Marginal Zone Lymphoma. San Miguel JF, Ocio EM, Mateo G, S�nchez ML, Gonz�lez B, Vidriales B,Guti�rrez N, Orfao A, Hern�ndez JM.

Evolution of IgM Monoclonal Gammopathies

Prognostic Factors Predicting Outcome Of Igm Mgus. Kyle RA, Therneau TM, Rajkumar SV, Remstein ED, Larson DR, Plevak MF, Melton LJ.

Presenting Features of IgM MGUS. Gwen L Nichols

Clinical Characteristics and Outcome of IgM-Related Disorders. C. Cesana, L. Barbarano, S. Miqueleiz, C. Lucchesini, F. Ricci, M. Varettoni, D. Filippini, M. Lazzarino, E. Morra

Prognostic Factors for Transformation in Asymptomatic IgM Monoclonal Gammopathies. Enrica Morra, Clara Cesana, Catherine Klersy, Luciana Barbarano, Sara Miqueleiz, Marzia Varettoni, Camilla Lucchesini, Francesca Ricci, and Mario Lazzarino.

Autoimmune Related Disorders in WM

Autoantibody (AAB) Activity In Waldenstr�m�s Macroglobulinemia (WM). Marvin J. Stone, Giampaolo Merlini, Virginia Pascual.

An Additional Example of the Diversity of the Manifestations Associated with Macroglobulinemia: The Schnitzler's Syndrome. JP Fermand.

Role Of The Fcg Receptors (FcgR) Iia And Iiia Polymorphisms In Waldenstrom�s Macroglobulinemia. S Poulain, I Dervite, X Leleu, J Fernandes, L Stalnikiewicz, S de Botton, P Duthilleul, P Morel

IgM Neuropathies in WM. T Levine, A Pestronk, J Florence, Al-Lozi, G Lopate, T Miller, I Ramneantu, W Waheed, M Stambuk, R Choksi.

Prognostic Markers in WM

The International Project for developing a Prognostic Index for Symptomatic Waldenstrom's Macroglobulinemia. Pierre Morel, Alain Duhamel, Meletios Dimopoulos, Jesus San Miguel, Bart Barlogie, Robert Kyle, V�ronique Leblond, Madhav Dhodapkar, Jason Mc Coy, Steven P. Treon, Paolo G. Gobbi and Giampaolo Merlini.

Prognostic Model for Disease Specific and Overall Mortality in 410 Newly Diagnosed Patients With WM. Irene M. Ghobrial, Rafael Fonseca, Morie A. Gertz, Matthew F. Plevak, Dirk R. Larson, Terry M. Therneau, Robert C. Wolf, Randi J. Hoffmann, John A. Lust, Thomas E. Witzig, Martha Q. Lacy, Angela Dispenzieri, S. Vincent Rajkumar, Stephen R. Zeldenrust, Philip R. Greipp, Robert A. Kyle.

Prognostic Value of Serum B2-Microglobulin in Patients with WM Requiring Treatment. A. Anagnostopoulos, D. Gika, K. Zervas, MC Kyrtsonis, A. Symeonidis, G. Pangalis, M.A. Dimopoulos.

Therapeutics in WM: Update on Nucleoside Analogue Trials

The WML Trial, An International Collaborative Phase III Study Of Chlorambucil Versus Fludarabine As Initial Therapy For Waldenstrom�s Macroglobulinaemia And Related Disorders. S A Johnson, R G Owen, D G Oscier, V Leblond, V Levy, U Jaeger, J F Seymour.

Treatment Of Waldenstr�m Macroglobulinemia With The Combination Of Fludarabine (Famp) And Cyclophosphamide (Cy): Results In 49 Patients (Pts). V Leblond, J Tamburini, V.L�vy, JP Fermand, C. Chateilex, L. Stalniewicz, P. Morel, A. Delmer, F. Dreyfus, MJ. Grange, B. Christian.

Fludarabine Combination Therapy is Highly Effective in Frontline and Salvage Treatment of Patients with Waldenstrom's Macroglobulinemia. Tam CS, Wolf MM, Westerman D, Januszewicz EH, Prince HM, Seymour JF.

Combination Therapy With Rituximab And Fludarabine In Waldenstrom's Macroglobulinemia. Steven P Treon, Andrew Branagan, Parveen Wasi, Christos A Emmanouilides, Stanley R Frankel, Andrew Lister, Pierre Morel, Jeffrey Matous, Sari Heitner Enschede and Eva Kimby.

Pentostatin, Cyclophosphamide And Rituximab: An Effective Regimen For Patients With Waldenstr�m�s Macroglobulinemia. Manfred Hensel, Matthias Villalobos, Martin Kornacker, Fatime Krasniqi.

Management Of Waldenstrom�s Macroglobulinemia (WM) In The Pre-Rituximab Era: Update On US Intergroup Trial S 9003 The Arkansas Autotransplant Experience. Athanasios Fassas, Madhav Dhodapkar, Jason McCoy, Erik Rasmussen, John Crowley and Bart Barlogie.

Monoclonal Antibody Therapy - Predictive Factors and Observations

Predictive Factors for Response to Rituximab in Waldenstrom's Macroglobulinemia. M.A. Dimopoulos, K. Zervas, D. Gika, A. Zomas, M.C. Kyrtsonis, A. Anagnostopoulos, N. Anagnostopoulos, G. Pangalis.

Polymorphisms In Fcriiia (CD16) Receptor Expression Are Associated With Clinical Response To Rituximab In Waldenstrom�s Macroglobulinemia. S. P. Treon, M. Hansen, A. Branagan, C. Emmanouilides, E. Kimby, S. Frankel, N. Touroutoglou, D. Maloney, K. C. Anderson, E. A. Fox.

The Initial �Flare�Of Igm Level After Rituximab Therapy In Patients Diagnosed With Waldenstrom Macroglobulinemia. Irene M Ghobrial, Rafael Fonseca, Philip R Greipp, Emily Blood, Montserrat Rue, David H Vesole, Morie A Gertz.

Paradoxical Increases In Serum Igm And Viscosity Levels Following Rituximab In Waldenstrom�s Macroglobulinemia. Andrew Branagan, Zachary Hunter, Daniel Ditzel Santos, Olivier Tournilhac, Robert Manning, and Steven P. Treon.

Therapeutics in WM: Update on Monoclonal Antibody Trials

CHOP Plus Rituximab (CHOP-R) in Waldenstrom's Macroglobulinemia. Zachary Hunter, Andrew Branagan and Steven P. Treon.

Thalidomide and Rituximab in Waldenstrom's Macroglobulinemia. Steven P Treon, Zachary Hunter, Daniel Ditzel Santos, and Andrew Branagan.

CD52 Anitgen Expression in Waldenstrom's Macroglobulinemia and activity of Alemtuzumab in Patients With Relapsed/Refractory Disease. RG Owen, AC Rawstron, A Osterborg, J Lundin, G Svensson, P Hillmen.

CD52 Is Expressed On Human Mast Cells And Is A Therapeutic Target For The Anti-CD52 Monoclonal Antibody Campath-1H In Waldenstrom's Macroglobulinemia And Mast Cell Disorders. Daniel Ditzel Santos, Evdoxia Hatjiarissi, Olivier Tournilhac, Lian Xu, Andrew Branagan, Zachary Hunter, Mayan Catsells, Kenneth C Anderson and Steven P Treon.

Campath 1-H in Waldenstrom's Macroglobulinemia. Daniel Ditzel Santos, Zachary R Hunter, Andrew R Branagan and Steven P Treon.

Theraputic Initiatives in WM

Autologous and Allogeneic Stem Cell Transplantation (SCT) for Treatment of Waldenstrom's Macroglobulinemia. P Dreger, S Stilgenbauer, B Seyfarth, D Bunjes, A Humpe, M Zeis, HA Horst, M Kneba, N Schmitz, H D�hner.

Biologically-Based Therapy in Waldenstrom's Macroglobulinemia. Nikhil C. Munshi, Jooeun Bae.

Novel Approaches to Transplant Therapy for Indolent Lymphomas. David G. Maloney.

A Phase I Trial Of Oblimersen Sodium For Relapsed Or Refractory Waldenstrom Macroglobulinemia. Morie A. Gertz, Susan M. Geyer, Brad Kahl, Ashraf Badros, Craig Reeder, Charles Erlichman.

Velcade in Waldenstrom's Macroglobulinemia. Steven P. Treon, Ashraf Badros, Robin M. Joyce, Sari L. Heitner Enschede, Ranjana Advani, Jeffrey Mattous, and Zachary Hunter.

Lymphoplasmacytic Cells And Mast Cells Are Targets For Imatinib Mesylate (Gleevec, Glivec) In Waldenstrom's Macroglobulinemia. Olivier Tournilhac, Daniel Ditzel Santos, Lian Xu, Evdoxia Hatjiharissi, Yu Tsu Tai, Laurie Catley, Zachary Hunter, Andrew Branagan, Renate Burger, Reshma Shringarpure, Joshua Boyce, Kenneth C Anderson and Steven P Treon.

Clinical and Laboratory Responses to Sildenafil in Waldenstrom's Macroglobulinemia. Daniel Ditzel Santos. Olivier Tournilhac, Andrew Branagan, Zachary Hunter, Lian Xu, Evdoxia Hatjiharissi and Steven P Treon.

Vascular Endothelial Growth Factor (VEGF) Is A Growth And Survival Factor In Waldenstrom's Macroglobulinemia. Steven Le Gouill, Oliver Tournilhac, Daniel Ditzel Santos, Klaus Podar, Lian Xu, Evdoxia Hatjiharissi, Yu-Tzu Tai, Zachary Hunter, Andrew Branagan, Kenneth C Anderson and Steven P Treon.

Clinical and Laboratory Observations in WM

IgA and IgG Hypogammaglobulinemia Persists in Most Patients with Waldenstrom's Macroglobulinemia Despite Theraputic Responses, Including Complete Remissions. Steven Treon, Andrew Branagan, Zachary Hunter, Daniel Ditzel Santos, Olivier Tournilhac, Evdoxia Hatjiharissi, Lian Xu and Robert Manning.

High Levels Of Soluble Immunoregulatory Receptors In Patients With Waldenstrom's Macroglobulinemia. Andrew R Branagan, Lian Xu, Zachary R Hunter, Daniel Ditzel Santos, Olivier Tournilhac, Evdoxia Hatjiharissi, Robert J Manning and Steven P Treon.

Heterogeneous Expression of CD5, CD10, and CD23 in Waldenstrom's Macroglobulinemia. Zachary Hunter, Robert Manning, Andrew Branagan, Olivier Tournilhac, Daniel Ditzel Santos, David Dorfman, and Steven P Treon.

IgM Myeloma: Evaluation of Immunophenotype Cytokine, and Molecular Features. Kartik Konduri, Surinder S. Sahota, Alex Tong, Joseph T. Newman, Marvin J. Stone.

A Novel Murine Model for Human Waldenstrom's Macroglobulinemia. Pierfrancesco Tassone, Paola Neri, Jeffery Kutok, Olivier Tournilhac, Daniel Ditzel Santos, Kenneth C Anderson, Steven P Treon and Nikhil C Munshi.